I was just reading the RPS journal and there was a note about some Sigma HSM lenses that may have an autofocus defect.
APO 50-500 f/4.5-6.3 DG OS HSM
Serial numbers 10633051-10972000
APO 120-400 f/4.5-5.6 DG OS HSM
Serial numbers 10574001-10972000
APO 150-500 f/5-6.3 DG OS HSM
Serial numbers 10674301-10972000
If you have one of these lenses you can contact Sigma on 01707 376 795. They will arrange to have the lens collecred, inspected and modified if necessary.